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This thesis project evaluated molecular differences between desmoplastic and replacement colorectal liver metastases, with the focus on the heterogeneity between ECs in livers colonized by CRCLM. Stratifying the sample specimen according to their mode of blood irrigation into sprouting angiogenesis or vessel cooption, I used a single cell RNA sequencing pipeline to establish a comprehensive dataset that captured all main cell populations. After conducting extensive literature research and publishing my findings, I focused on studying the heterogeneity of endothelial cells in the adjacent li...
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