Melanie Börries

Profile of the Multicenter Cohort of the German Cancer Consortium's Clinical Communication Platform

Abstract: Treatment concepts in oncology are becoming increasingly personalized and diverse. Successively, changes in standards of care mandate contin...

Protein Abundance of AKT and ERK Pathway Components Governs Cell Type-specific Regulation of Proliferation

Abstract: Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involv...

The Oncogenic Fusion Protein DNAJB1-PRKACA Can be Specifically Targeted by Peptide-based Immunotherapy in Fibrolamellar Hepatocellular Carcinoma

Abstract: The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma, a lethal disease lacking specific the...

Phase II Trial of Hypomethylating Agent Combined with Nivolumab for Acute Myeloid Leukaemia Relapse After Allogeneic Haematopoietic Cell Transplantation - Immune Signature Correlates with Response

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The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses

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MIRACUM: Medical Informatics in Research and Care in University Medicine

A Large Data Sharing Network to Enhance Translational Research and Medical Care

Abstract: Introduction: This article is part of the Focus Theme of Methods of Information in Medicine on the German Medical Informatics Initiative. Si...

Comprehensive Cancer Predisposition Testing Within the Prospective MASTER Trial Identifies Hereditary Cancer Patients and Supports Treatment Decisions for Rare Cancers

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BRAF Δβ3-αC In-frame Deletion Mutants Differ in Their Dimerization Propensity, HSP90 Dependence, and Druggability

BRAF [delta][beta]3-[alpha]C In-frame Deletion Mutants Differ in Their Dimerization Propensity, HSP90 Dependence, and Druggability

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Multicentric Pilot Study to Standardize Clinical Whole Exome Sequencing (WES) for Cancer Patients

Abstract: A growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer pa...

Constitutional SAMD9L Mutations Cause Familial Myelodysplastic Syndrome and Transient Monosomy 7

Abstract: Familial myelodysplastic syndromes arise from haploinsufficiency of genes involved in hematopoiesis and are primarily associated with early-...

Bcl-xL as Prognostic Marker and Potential Therapeutic Target in Cholangiocarcinoma

Abstract: Intrahepatic, perihilar, and distal cholangiocarcinoma (iCCA, pCCA, dCCA) are highly malignant tumours with increasing mortality rates due t...

A Distinct CD38+CD45RA+ Population of CD4+, CD8+, and Double-negative T Cells is Controlled by FAS

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In Vivo Kinetics of Early, Non-random Methylome and Transcriptome Changes Induced by DNA-hypomethylating Treatment in Primary AML Blasts

Abstract: Despite routine use of DNA-hypomethylating agents (HMAs) in AML/MDS therapy, their mechanisms of action are not yet unraveled. Pleiotropic e...

Implementing Pharmacogenomic Clinical Decision Support Into German Hospitals

Abstract: Background: Pharmacogenomic Clinical Decision Support Systems (CDSS) are considered to be the most feasible tool for adopting pharmacogenomi...